胚胎干细胞研究湖北省重点实验室
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2025年度代表性研究成果
2026-06-10 18:22  

本年度,实验室固定研究成员在学术刊物上发表署名武当特色中药研究湖北省重点实验室论文102篇,其中SCI收录62篇(151区,482)。其中授权发明专利14项,另申请发明专利8项。主编或参编专著8本,获省科技进步一、二、三等奖各1项。

1.论文

序号

论文名称

刊物名称

分区

影响因子

作者

1

Exploring the Complex Relationship Between Air Pollution and MASLD: Key Considerations for Future Research

Journal of hepatology

1

33.0

罗智环

2

Reimagining HRME's Global Role: Operator Expertise Gap Undermines Cost-Effective ESCN Screening

Gastroenterology

1

25.9

左殿宝

3

Dedicator of Cytokinesis 2 regulates cytoskeletal actin dynamics and is essential for platelet biogenesis and functions

Cardiovascular research

1

13.3

汪选斌

4

A simple and rapid microfluidic size-deformability cytometer for assessing tumor cell metastatic potential and drug treatment effects

Chemical Engineering Journal

1

13.2

陈悦

5

Corrigendum to "Nucleic acid-based nanogels with 'offensive and defensive' effects for enhanced chemo-immunotherapy"

Journal of controlled release

1

11.5

李兵

6

A chromosome-scale genome assembly and epigenomic profiling reveal temperature-dependent histone methylation in iridoid biosynthesis regulation in Scrophularia ningpoensis

Horticulture research

1

8.5

张勇洪

7

Author Correction: Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells

Acta Pharmacologica Sinica,

1

8.4

刘莹

8

Angoroside C: A potent AMPK activator in the aqueous extract of Scrophularia ningpoensis, alleviates metabolic syndrome in db/db mice

Phytomedicine

1

8.3

郑涛

9

Withaferin A maintained microbiome and metabolome features in A53T transgenic mice via multi-omics integrated analysis

Phytomedicine

1

8.3

桑明

10

Linarin attenuates hyperuricemic nephropathy by modulating Nrf2/Keap1 and TLR4/NF-κB signaling pathways: Linarin attenuates hyperuricemic nephropathy

Phytomedicine

1

8.3

李飞

11

Sculponeatin A induces mitochondrial dysfunction in non-small cell lung cancer through WWP2-mediated degradation of mitochondrial STAT3

British journal of pharmacology

1

7.7

刘莹

12

Liquid-liquid phase separation of GPS2-LATS1 promotes colorectal cancer progression by reprogramming lipid metabolism

Oncogene

1

7.3

刘莹

13

Pachymic Acid Ameliorates Fructose-Driven Hyperuricemic Nephropathy in Mice by Suppressing Ferroptosis via Activating Nrf2/GPX-4 Pathway

Journal of agricultural and food chemistry

1

6.2

李珊

14

The role of glutathione for oxidative stress and pathogenicity of Streptococcus suis

Virulence

1

5.4

杨霞

15

Inverse association between dietary fiber intake and gallstone disease in U.S. adults: a cross-sectional study from the NHANES database

Frontiers in Nutrition

1

5.1

桑明

16

Copper overload induces lifespan shortening through activating mitochondrial respiration in Caenorhabditis elegans

Journal of hazardous materials

2

11.3

汪选斌

17

Research letter: the global clinical trial landscape for non-alcoholic fatty liver disease (NAFLD) current status and future prospects

International journal of surgery

2

10.3

汪选斌

18

Identification of CACNB1 protein as an actionable therapeutic target for hepatocellular carcinoma via metabolic dysfunction analysis in liver diseases: An integrated bioinformatics and machine learning approach for precise therapy

International journal of biological macromolecules

2

8.5

汪选斌

19

Cepharanthine-induced mitophagy through regulation of FBXL4-BNIP3 drives ferroptosis leading to robust anti-lung cancer efficacy

Free radical biology & medicine

2

8.2

冷帆

20

Ultra-fast preparing carbon nanotube-supported Ni-Fe bimetallic compounds as robust electrocatalysts for oxygen evolution reaction

Fuel

2

7.5

李兵

21

The high-quality genome sequence of Agroathelia rolfsii (Syn Sclerotium rolfsii), the causal agent of southern blight in Coptis chinensis

Scientific Data

2

6.9

张勇洪

22

Chromosome-scale genome assembly and annotation of Huzhang (Reynoutria japonica)

Scientific Data

2

6.9

张勇洪

23

Characterization of polysaccharides fractions from Trillium tschonoskii Maxim. and assessment of their antioxidant and immunomodulatory activities

Carbohydrate Polymer Technologies and Applications

2

6.5

郝新才

24

Ginger-Derived Exosome-Like Nanoparticles: The Effect of Extraction Methods on Metabolites and in vitro Anti-Lung Cancer Activity

International journal of nanomedicine

2

6.5

刘经健

25

Forsythoside A Alleviates Acute Alcoholic Liver Injury by Binding to TLR4 to Inhibit the Activation of the NF-κB Pathway

Phytotherapy research : PTR

2

6.3

高小康

26

SPME-GC/MS profiling reveals flavor benefits of Polygonatum sibiricum in Yunyang Huangjiu

Journal of Agriculture and Food Research

2

6.2

张勇洪

27

Small-molecule fluorescent probes for imaging intracellular amyloid toxicity induces ferroptosis via HClO fluctuation in Alzheimer's disease

Analytica chimica acta

2

6

陈淼

28

Targeting CD16A on NK cells and GPC3 in hepatocellular carcinoma: development and functional validation of a therapeutic bispecific antibody

Frontiers in Immunology

2

5.9

左殿宝

29

Therapeutic strategies for adrenocortical carcinoma: integrating genomic insights molecular targeting

Frontiers in Immunology

2

5.9

汪选斌

30

The clinical significance of T-cell regulation in hypertension treatment

Frontiers in Immunology

2

5.9

陈俊

31

Efficacy of natural killer T and gammadelta T cells in mesothelin-targeted immunotherapy of pancreatic cancer

Frontiers in Immunology

2

5.9

左殿宝

32

Arbuscular mycorrhizal fungi enhance drought resilience and bioactive compound accumulation in Polygonum cuspidatum

Plant physiology and biochemistry : PPB

2

5.7

张泽志

33

Nucleic acid-based nanogels for drug deliveryFrom construction strategies to intelligent applications

Colloids and surfaces. B, Biointerfaces

2

5.6

李兵

34

Calycosin extracted from Astragali Radix reduces NETs formation to improve renal fibrosis via TLR4/NF-κB pathway

Journal of ethnopharmacology

2

5.4

李飞

35

One step laser-induced Fe3O4 loaded 3D graphene electrode for electrochemical sensing and supercapacitor applications

Microchemical Journal

2

5.1

艾益静

36

A novel ultra-sensitive fluorescent probe for monitoring and imaging drug-induced/inhibited ferroptosis-mediated liver injury model via peroxynitrite fluctuations

Microchemical Journal

2

5.1

陈淼

37

Pristimerin induces Noxa-dependent apoptosis by activating the FoxO3a pathway in esophageal squamous cell carcinoma

Chinese journal of natural medicines

2

4.9

赵群

38

Salidroside alleviates ethanol exposure-exacerbated hepatic insulin resistance in diabetic mice

International immunopharmacology

2

4.7

凌旭

39

A high-sensitivity ESIPT-based fluorescent probe with a large stokes shift for HS detection and imaging in U251 cells and glioma mouse models

Bioorganic Chemistry

2

4.7

孙西尚

40

Recent advances in the Total synthesis and structural modification of Ecteinascidin-743

Bioorganic chemistry

2

4.7

郭俊

41

Chalcone-Mediated and unexpected rearrangement preparation of 1H-pyrazol-furo[2,3-d]pyrimidine derivatives as potent antitumor agents

Journal of Molecular Structure

2

4.7

胡扬根

42

Overlooked Ligand Role of Pyridine Substrate in Site Selectivity of Rare-Earth-Catalyzed C-H Alkylation with Alkenes

Inorganic chemistry

2

4.7

罗伦

43

Mechanisms and Origins of Regioselectivity in Rare-Earth-Catalyzed C-H Functionalization of Anisoles and Thioanisoles

Inorganic chemistry

2

4.7

罗伦

44

Regulating p53/PUMA pathway on cervical cancer C-33A and HeLa cells of Acanthus ilicifolius Linn alkaloid 2-benzoxazolinone derivatives

Journal of Molecular Structure

2

4.7

王红梅

45

Theoretical Insights into Rare-Earth-Catalyst-Controlled Diastereo- and Enantioselective [3 + 2] Annulation of Aromatic Aldimines with Styrenes

Inorganic chemistry

2

4.7

罗伦

46

Ibuprofen-furo[2,3-d]pyrimidine-based hybrid bearing triazole, hydrazide and oxadiazole as potent antitumor agents: Design and synthesis and activity evaluation

Journal of Molecular Structure

2

4.7

胡扬根

47

A highly sensitive ESIPT fluorescent probe for visualization of HK2-mediated lung cancer progression via imaging nitroreductase.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2

4.6

孙西尚

48

Non-traditional lipid biomarkers in atherosclerotic cardiovascular disease: pathophysiological mechanisms and strategies to address residual risk

Frontiers in Endocrinology

2

4.6

陈俊

49

Ergothioneine Attenuates CCl4-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Apoptosis via Regulating LKB1/Nrf2 Pathway

FASEB journal

2

4.2

余惠凡

50

Global lysine crotonylation profiling reveals metabolic and stress-responsive mechanisms in Reynoutria japonica

Journal of plant physiology

2

4.1

郑兰兰

51

Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2′ Amino Acid Replacements

Toxins

2

4

罗旭东

52

Immune Dysregulation at the Maternal–Fetal Interface Exacerbates Adverse Pregnancy Outcomes in an Inflammatory Arthritis Murine Model

Biomedicines

2

3.9

陈俊

53

Epigallocatechin3Gallate Mitigates Atopic DermatitisLike Skin Lesions and Psychiatric Comorbidities by Reducing Oxidative Stress

Food Science & Nutrition

2

3.8

王天帅

54

Mass spectrometry imaging analysis of traditional Chinese medicine by laser ablation-dielectric barrier discharge ionization

Analytical and Bioanalytical Chemistry

2

3.8

陆桥

55

Cornus officinalis Extract Ameliorates Fructose-Induced Hepatic Steatosis in Mice by Sustaining the Homeostasis of Intestinal Microecology and Lipid Metabolism

Food science & nutrition

2

3.8

汪选斌

56

Terretonins P-Y, Meroterpenoids with Distinct 6/6/6/6 and 6/6/6/5 Ring Systems from the Soil-Derived Fungus Aspergillus sp.

Journal of natural products

2

3.6

胡正西

57

Identification and preclinical efficacy evaluation of two lytic bacteriophages targeting highly virulent and multidrug-resistant Klebsiella pneumoniae

Annals of Clinical Microbiology and Antimicrobials

2

3.6

桑明

58

Functional characterization of a common XIa inhibitory Kunitz-domain Shp4 from nine schistosoma secreted proteins with diverse C-terminal fragments

PLoS neglected tropical diseases

2

3.4

陈宗运

59

Identification of plasticizers using thermal desorption dielectric barrier discharge ionization mass spectrometry

The Analyst

2

3.3

陆桥

60

The miR-137/DEL-1 axis-induced apoptosis as a potential heart failure mechanism

International journal of cardiology

2

3.2

罗志焕

61

Collection, Evaluation, and New Cultivar Breeding of Actinidia chinensis var. chinensis in Wudang Mountains, China

Horticulturae

2

3

肖涛

62

Innovative molecular intervention and precision therapy for atherosclerosis

Frontiers in Cardiovascular Medicine

2

2.9

张琼

63

A systematic review of the connection between serum uric acid levels and the risk of cardiovascular disease

Frontiers in Cardiovascular Medicine

2

2.9

魏英

64

Qiang-Xin 1 formula improves cardiac function and alleviates myocardial injury in lipopolysaccharide-induced septic mice by activating calcium/calmodulin-dependent protein kinase I-mediated mitophagy

Journal of Ethnopharmacology

3

5.4

曹鹏

65

The next frontier in antibody-drug conjugates: challenges and opportunities in cancer and autoimmune therapy

Cancer drug resistance (Alhambra, Calif)

4

5.2

陈俊

66

The application of post-ionization strategy in atmospheric pressure mass spectrometry imaging

Microchemical Journal

3

5.1

陆桥

67

Population pharmacokinetics/pharmacodynamics and safety of YPEG-rhGH in elderly subjects

Frontiers in pharmacology

3

4.8

翟学佳

68

Integrated metabolomic and transcriptomic profiling reveals leaf-specific flavonoid biosynthesis in Paris polyphylla Sm

BMC Plant Biology

3

4.8

李志浩

69

Regulating PTEN/PI3K/AKT signaling pathway on HeLa cells of Rhopaladins' analog RPDPD

Journal of Molecular Structure

3

4.7

曾小华

70

An ultrasensitive ESIPT fluorescent probe enables selective labeling and imaging of nitroreductase both in vitro and in vivo

Journal of Molecular Structure

3

4.7

陈淼

71

Feasibility of galectin-3 as a diagnostic biomarker and therapeutic target for inflammatory bowel disease

European journal of pharmacology

3

4.7

余惠凡

72

The study of the therapeutic effect and preliminary mechanism of EGCG on recurrent aphthous ulcer

Scientific reports

3

3.9

赵永红

73

The correlation between the atherogenic index of plasma and the severity of coronary artery disease in acute myocardial infarction patients under different glucose metabolic states

Scientific Reports

3

3.9

陈俊

74

Cu@ZIF-8 coupled to UPLC-UV for rapid and sensitive analysis of emodin and rhein in urine samples

Journal of pharmaceutical and biomedical analysis

3

3.1

朱军

75

Corrigendum to "Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity"

Archives of biochemistry and biophysics

3

3

刘莹

76

Visualization of the distribution of carbendazim on the arabidopsis leaf surface by VUV-postionization mass spectrometry

Analytical methods

3

2.7

陆桥

77

Development and validation of a risk prediction model for meropenem-related thrombocytopenia in patients with pulmonary infection

BMC Pharmacology and Toxicology

3

2.7

于慧斌

78

Economic and facile extraction and analysis of osthole in Fructus cnidii for large-scale production

Analytical methods : advancing methods and applications

3

2.7

凌旭

79

Laser-induced acoustic desorption coupled with dielectric barrier discharge ionization mass spectrometry for analysis of thermally labile compounds

Analytical Sciences

4

2

陆桥

80

The mediating role of personality traits and internet addiction among medical students: a mediation analysis of demographic and behavioral factors

Frontiers in Education

4

1.9

张琼

81

An Association Between GLP-1 Receptor Expression on Regulatory T Cells and the Severity of Coronary Artery Stenosis and Inflammatory Dysregulation in Coronary Heart Disease

Reviews in Cardiovascular Medicine

4

1.3

陈俊

82

捻转血矛线虫环鸟苷酸信号通路重要基因功能预测

湖北医药学院学报

/

/

何 莉

83

丁香酚抑制肺炎克雷伯菌毒力因子的表达及其机制研究

湖北医药学院学报

/

/

汪静杰

84

生姜外泌体提取、表征、成分分析及应用的研究进展

药学前沿

/

/

朱军

85

基于火棘果总黄酮提取工艺优化为例的产教融合课题设计

广州化工

/

/

赵永恒

86

高效液相色谱法分析检测注射用还原型谷胱甘肽中杂质成分

湖北医药学院学报

/

/

朱军

87

4个猕猴桃新品种果实品质及可溶性固形物含量空间分布特点

果树学报

/

/

肖涛

88

Galectin-3作为炎症信号在溃疡性结肠炎中的研究进展.

中国药理学通报

/

/

潘祥林

89

LC-MS/MS在儿茶酚胺及其代谢物检测中的研究进展

分析测试学报

/

/

陆桥

90

基于ImageJ的药用植物黄精染色体核型分析

湖北农业科学

/

/

张勇洪

91

基于方剂学和液-质联用方法的武当道墨质量分析研究

医学研究与教育

/

/

金志雄

92

胡椒碱对CCl4诱导小鼠急性肝损伤的保护作用

中南民族大学学报(自然科学版)

/

/

余惠凡

93

AHM赋权联合TOPSIS法评价热毒宁注射液临床应用的合理性

湖北医药学院学报

/

/

魏娟

94

美罗培南相关肝损伤的影响因素及其预测价值

临床肝胆病杂志

/

/

于慧斌

95

重楼皂苷调控MAPK信号通路对宫颈癌增殖和凋亡的影响

湖北医药学院学报

/

/

李鹏

96

基于网络药理学和实验验证探究重楼皂苷Ⅰ抗宫颈癌的作用机制

现代药物与临床

/

/

李志浩

97

朱砂精酸生物合成体系的构建和应用

生物工程学报

/

/

李志浩

98

白芨根腐病菌腐皮镰孢(Fusarium solani)拮抗菌筛选及抑菌机制

微生物学通报

/

/

金志雄

99

樱桃果汁冻干粉通过调控尿酸转运蛋白减轻高尿酸性肾损伤

现代食品科技

/

/

余惠凡

100

钩毛茜草素C靶向cathepsin D诱导自噬体积累抑制胃癌的作用研究

中国中药杂志

/

/

刘莹

101

基于miRNA测序探究重楼皂苷抗炎的关键因子

中国医院药学杂志

/

/

李志浩

102

结合天然药物化学实验教学的实习课题设计与探索——以艾叶总黄酮的提取与活性研究为例

云南民族大学学报(自然科学版)

/

/

郝新才

2.专利

序号

授权的专利名称

知识产权编号

申请或授权类型

发明人

1

含布洛芬-香豆素骨架化合物及其应用

ZL 2022 1 1173554.2

授权发明专利

胡扬根

2

一种具有抗肺癌活性的化合物及其制备方法和应用

ZL 2023 1 0531048.4

授权发明专利

曾小华

3

一种纳米药物G3T19-mPEG在制备治疗牙周炎的药物中的应用

ZL 2024 1 1199365.1

授权发明专利

姚悦欣参与

4

一种探针簇、试剂盒及其在检测艰难拟梭菌中的应用

ZL 2024 1 0974420.3

授权发明专利

姚悦欣参与

5

一种改善过敏性气喘的中药组合物及其制备方法

CN202510583860.0

授权发明专利

成俊

6

一种解鸟氨酸拉乌尔菌抗菌肽及应用

CN202511271002.9

授权发明专利

金志雄

7

一种嗜黏蛋白阿克曼菌或其外囊泡在制备治疗血吸虫病药物中的应用

CN202511179029.5

授权发明专利

赵燕清

8

受体辅助蛋白6及其抑制剂在制备治疗口腔鳞状细胞癌药物中的应用

CN202411653269.X

授权发明专利

夏凌云

9

一种钩虫Kunitz多肽及其抗凝血应用

CN202211580824.1

授权发明专利

叶祥东

10

Nrsn1在制备神经干细胞分化为神经元细胞药物中的应用

CN202510969680.6

授权发明专利

于莉参与

11

一种黄花香茶菜甲素纳米乳的制备及应用

CN202410305881.1

授权发明专利

刘莹

12

一种镧系金属有机框架复合材料及其制备方法和应用

CN202411691574.8

授权发明专利

武伦

13

嗜黏蛋白阿克曼氏菌在改善和治疗伯氏疟原虫所致脑型疟疾中的应用

CN202411528863.6

授权发明专利

赵燕清

14

一种阿米替林喷雾剂及其制备方法与应用

CN202411287559.7

授权发明专利

叶方

15

一种蜂胶温敏原位凝胶及其制备方法和应用

CN202511103919.8

申请发明专利

郝新才

16

一组具有快速杀菌活性的多肽及其用途

CN202510873806.X

申请发明专利

叶祥东

17

一组破坏细胞膜的蝎源抗菌肽及其用途

CN202510873816.3

申请发明专利

叶祥东

18

一种茶花粉总黄酮提取物及其制备方法和应用

CN202511116655.X

申请发明专利

郝新才

19

AKK/或其外膜囊泡诱导巨噬细胞极化方法及在制备促进巨噬细胞吞噬感染红细胞的药物中的应用

CN202510974893.8

申请发明专利

赵燕清

20

一种黄精来源外泌体样纳米囊泡制备方法及其在抗肿瘤药物中的应用

CN202510512624.X

申请发明专利

刘经健

21

一种苍术愈伤组织诱导、增殖培养基及培养方法

CN202510627082.0

申请发明专利

叶峥秀

22

一种治疗结肠炎的联合用药物及其应用

CN202511305377.2

申请发明专利

郝明月

3.专著

序号

专著名称

年份

出版社

主编或参编人员

1

天然产物药理学

2025

上海科学技术出版社

徐宏喜,汪选斌,齐红艺

2

医学生物化学

2025

人民卫生出版社

严世荣

3

护理药理学

2025

高等教育出版社

李飞

4

药理学(案例版)

2025

科学出版社

李飞

5

药理学

2025

科学出版社

李飞

6

药物警戒

2025

人民卫生出版社

赵利军

7

医学实验动物学

2025

人民卫生出版社

严世荣

8

临床营养学

2025

科学出版社

郭怀兰



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