胚胎干细胞研究湖北省重点实验室
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2024年度代表性研究成果
2025-06-15 18:22  


本年度,实验室固定研究成员在学术刊物上发表署名武当特色中药研究湖北省重点实验室论文105篇,其中SCI收录62篇(161区,372)。其中授权发明专利6项,另申请发明专利5项。主编或参编专著4本,获得中华中医药学会科学技术奖三等奖1项,作为第一完成人获省科技进步三等奖2项,参与4项。

1.论文

序号

论文名称

刊物名称

分区

影响因子

作者

1

Low-temperature photothermal-chemotherapy enhancing tumor immunotherapy by tetrahedral framework nucleic acids nanogels based drug delivery system

Chemical Engineering Journal

1

13.3

李兵

2

Midline-1 regulates effector T cell motility in experimental autoimmune encephalomyelitis via mTOR/microtubule pathway.

Theranostics

1

12.4

陈俊

3

Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model

Journal of Nanobiotechnology

1

10.6

桑明

4

Dedicator of Cytokinesis 2 regulates cytoskeletal actin dynamics and is essential for platelet biogenesis and functions.

Cardiovascular research

1

10.2

汪选斌

5

A fungal hyphae-derived biomass carbon for magnetic solid-phase extraction of the organochlorine pesticides in water samples, tea beverages, and Chinese traditional medicines before gas chromatography-tandem mass spectrometry determination.

Food chemistry

1

8.5

樊靓

6

Preparation, characterization, and antitumor immunity activity of polysaccharide fractions from Radix Tinosporae in vivo.

International journal of biological macromolecules

1

7.7

郝新才

7

Restraining the shuttle effect of polyiodides and modulating the deposition of zinc ions to enhance the cycle lifespan of aqueous Zn-I2 batteries.

Chemical science

1

7.6

李兵

8

Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity to Influence Neutrophil Recruitment.

Arteriosclerosis, thrombosis, and vascular biology

1

7.4

汪选斌

9

Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells

Acta Pharmacologica Sinica

1

6.9

刘莹

10

Immunogenic cell death inducers for cancer therapy: An emerging focus on natural products

Phytomedicine

1

6.7

张乐乐

11

Visual Detection of LPS at the Femtomolar Level Based on Click Chemistry-Induced Gold Nanoparticles Electrokinetic Accumulation.

Analytical chemistry

1

6.7

陈悦

12

Ultra-fast preparing carbon nanotube-supported Ni-Fe bimetallic compounds as robust electrocatalysts for oxygen evolution reaction

Fuel

1

6.7

李兵

13

Linarin attenuates hyperuricemic nephropathy by modulating Nrf2/Keap1 and TLR4/NF-κB signaling pathways: Linarin attenuates hyperuricemic nephropathy.

Phytomedicine

1

6.7

李飞

14

Polyaspers A and B, the First ErgosterolPolyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp. TJ507

Chinese Journal of Chemistry

1

5.5

郝新才

15

Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism

Communications Biology

1

5.2

杜士明

16

Integrated multi-omics profiling highlights the benefits of resveratrol hydroxypropyl-β-cyclodextrin inclusion complex for A53T transgenic mice through the microbiota-gut-brain axis.

Food & function

1

5.1

桑明

17

Mid1 Promotes Synovitis in Rheumatoid Arthritis via Ubiquitin-dependent Post-translational Modification.

Pharmacological research

2

9.1

陈俊

18

Integration of transcriptomic analysis and multiple machine learning approaches identifies NAFLD progression-specific hub genes to reveal distinct genomic patterns and actionable targets

Journal of Big Data

2

8.6

汪选斌

19

Deciphering the Therapeutic Potential of Myeloid-Specific JAK2 Inhibition in Acute Respiratory Distress Syndrome.

Mucosal immunology

2

7.9

陈俊

20

G protein pathway suppressor 2 suppresses aerobic glycolysis through RACK1-mediated HIF-1α degradation in breast cancer.

Free radical biology & medicine

2

7.1

刘莹

21

Combined Hydroxyethyl Starch Luteolin Nanocrystals for Effective Anti-Hyperuricemia Effect in Mice Model.

International journal of nanomedicine

2

6.6

李飞

22

Sweet triterpenoid glycoside from Cyclocarya paliurus ameliorates obesity-induced insulin resistance through inhibiting the TLR4/NF-κB/NLRP3 inflammatory pathway

Current Research in Food Science

2

6.2

余惠凡

23

Pomegranate polyphenol punicalin ameliorates lipopolysaccharide-induced memory impairment, behavioral disorders, oxidative stress, and neuroinflammation via inhibition of TLR4-NF-кB pathway.

Phytotherapy research : PTR

2

6.1

陈鹏

24

Permeation enhancer decorated nanoparticles for oral delivery of insulin: manipulating the surface density of borneol and PEG for absorption barriers

Biomaterials science

2

5.8

罗寒

25

Rational synthesis and evaluation of 2,4-diamino-thieno[2,3-d]pyrimidines as antitumor agents

Journal of Saudi Chemical Society

2

5.8

胡扬根

26

Letter to the editor regarding “Intraoperative hypotension during liver transplantation and postoperative outcomes: Retrospective cohort study”

Journal of Clinical Anesthesia

2

5

罗志焕

27

Chiral recognition and amplification of melibiose based on (R)/(S)-phenylethylamine calix[4]arene modified gold surface

Microchemical Journal

2

4.9

马俊凯

28

A novel ultra-sensitive fluorescent probe for monitoring and imaging drug-induced/inhibited ferroptosis-mediated liver injury model via peroxynitrite fluctuations

Microchemical Journal

2

4.9

艾益静

29

Sirt1 alleviates osteoarthritis via promoting FoxO1 nucleo-cytoplasm shuttling to facilitate autophagy

International Immunopharmacology

2

4.8

许毛

30

Calycosin extracted from Astragali Radix reduces NETs formation to improve renal fibrosis via TLR4/NF-κB pathway.

Journal of ethnopharmacology

2

4.8

李飞

31

Resveratrol Inhibits VDAC1-Mediated Mitochondrial Dysfunction to Mitigate Pathological Progression in Parkinson's Disease Model.

Molecular neurobiology

2

4.6

孙晓东

32

Methylated urolithin A, mitigates cognitive impairment by inhibiting NLRP3 inflammasome and ameliorating mitochondrial dysfunction in aging mice

Neuropharmacology

2

4.6

陈鹏

33

Sedum aizoon L.: a review of its history, traditional uses, nutritional value, botany, phytochemistry, pharmacology, toxicology, and quality control

Frontiers in Pharmacology

2

4.4

郝新才

34

The role and mechanism of HIF-1α-mediated glypican-3 secretion in hypoxia-induced tumor progression in hepatocellular carcinoma

Cellular Signalling

2

4.4

严世荣

35

Ligand-Dominated Activation of CO2 and CS2 by the Putative Nickel Phosphiniminato Intermediates.

Inorganic chemistry

2

4.3

罗伦

36

Theoretical Insights into Rare-Earth-Catalyst-Controlled Diastereo- and Enantioselective [3 + 2] Annulation of Aromatic Aldimines with Styrenes.

Inorganic chemistry

2

4.3

罗伦

37

Ibuprofen-furo[2,3-d]pyrimidine-based hybrid bearing triazole, hydrazide and oxadiazole as potent antitumor agents: Design and synthesis and activity evaluation

Journal of Molecular Structure

2

4

胡扬根

38

Gambogenic acid induces apoptosis via upregulation of Noxa in oral squamous cell carcinoma.

Chinese journal of natural medicines

2

4

余贤军

39

Analysis of chlorogenic acid and two flavonoids in mulberry leaves of different harvest periods and origins and HPLC fingerprint study for quality control

Journal of Food Composition and Analysis

2

4

凌旭

40

Hyparillums A and B: polycyclic polyprenylated acylphloroglucinols from Hypericum patulum.

Chinese journal of natural medicines

2

4

郝新才

41

Regulating p53/PUMA pathway on cervical cancer C-33A and HeLa cells of Acanthus ilicifolius Linn alkaloid 2-benzoxazolinone derivatives

Journal of Molecular Structure

2

4

王红梅

42

Characterization of Kunitz-Domain Anticoagulation Peptides Derived from Acinetobacter baumannii Exotoxin Protein F6W77

Toxins

2

3.9

叶祥东

43

Glucagon-like peptide-1 receptor agonists in neoplastic diseases

Frontiers in Endocrinology

2

3.9

陈俊

44

Function and Mechanism of Antiviral Wasp Venom Peptide Protopolybia-MP III and Its Derivatives against HSV-1.

Toxins

2

3.9

叶祥东

45

Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2’ Amino Acid Replacements

Toxins

2

3.9

罗旭东

46

Comparative transcriptomic analysis provides insights into the regulation of root-specific saponin production in Panax japonicus

Scientific Reports

2

3.8

张勇洪

47

Inhibitory effect of aqueous extract of Scrophularia ningpoensis on β-cell pyroptosis in diabetic mice

Journal of Functional Foods

2

3.8

郑涛

48

Luteolin ameliorates hyperuricemic nephropathy by activating urate excretion and Nrf2/HO1/NQO1 antioxidant pathways in mice

Food Science & Nutrition

2

3.5

李飞

49

In-Situ Metabolic Profiling of Different Kinds of Rheum palmatum L. by Laser Desorption–Dielectric Barrier Discharge Ionization Mass Spectrometry Imaging

Metabolites

2

3.4

陆桥

50

The miR-26b/CTGF axis: A promising therapeutic mechanism for managing myocardial fibrosis post myocardial infarction.

International journal of cardiology

2

3.2

罗志焕

51

Mitochondrial dysfunction due to miR-210/Drd5/ROS axis is a potential mechanism of heart failure.

International journal of cardiology

2

3.2

罗志焕

52

LKB1/AMPK treats myocardial disease by boosting mitochondrial function

International Journal of Cardiology

2

3.2

罗志焕

53

The augmentation of cytotoxic immune cell functionality through physical exertion bolsters the potency of chemotherapy in models of mammary carcinoma.

Cancer medicine

2

2.9

桑明

54

Recent progress in energy-saving electrocatalytic hydrogen production via regulating the anodic oxidation reaction.

Physical chemistry chemical physics : PCCP

3

2.9

李兵

55

AILDE Computer-Aided Discovery of Novel Ibuprofen-Coumarin Antitumor Lead Compounds Targeting Cyclooxygenase-2

ACS omega

3

3.7

吴丰旭

56

Liver-derived Exosomal miRNA in NAFLD: Mechanisms of Action, Biomarkers, and Therapeutic Applications.

Current medicinal chemistry

3

3.5

李珊

57

Determination of doxorubicin in plasma and tissues of mice by UPLC-MS/MS and its application to pharmacokinetic study

Heliyon

3

3.4

肖雪

58

Polyphyllin VII as a potential medication for targeting epithelial mesenchymal transitionin in thyroid cancer

Journal of Pharmacological Sciences

3

3

杜伯雨

59

High-sensitivity formaldehyde gas sensor based on Ce-doped urchin-like SnO2 nanowires derived from calcination of Sn-MOFs

Frontiers of Materials Science

3

2.5

校伟

60

The functions of apolipoproteins and lipoproteins in health and disease

Molecular Biomedicine

4

6.3

马俊凯

61

Advancements in Cardiovascular Disease Research Affected by Smoking

Reviews in Cardiovascular Medicine

4

1.9

陈俊

62

Mechanistic Evaluation of EGCG against Atopic Dermatitis: An in Vivo and in Silico Study

Natural Product Communications

4

1.5

王天帅

63

The direct STAT3 inhibitor 6-ethoxydihydrosanguinarine exhibits anticancer activity in gastric cancer

Acta Materia Medica

-

-

刘莹

64

Mechanism and use strategy of uric acid-lowering drugs on coronary heart disease

IJC Heart & Vasculature

-

-

张琼

65

经典名方散偏汤标准汤剂及颗粒剂工艺优化与评价

中华中医药杂志

-

-

高小康

66

预防禽类呼吸道疾病的中药固体空气清新剂研制和抑菌效果分析

中国兽医杂志

-

-

高小康

67

娑罗子中七叶皂苷A的超声-微波协同提取工艺优化

湖北医药学院学报

-

-

戈振凯

68

HPLC双波长同时测定麻杏石甘汤中4个有效成分含量

广州化工

-

-

郝新才

69

见血清提取物对LPS诱导BV-2小胶质细胞介导神经炎症的作用及成分分析

中国中药杂志

-

-

郝新才

70

樱桃果汁冻干粉通过调控尿酸转运蛋白减轻高尿酸性肾损伤

现代食品科技

-

-

李飞

71

Hippo-YAP/TAZ信号通路在器官纤维化中的作用

中南大学学报(医学版)

-

-

李飞

72

鄂西北地区疏花蛇菰的生药学研究

湖北医药学院学报

-

-

李飞

73

响应面法优化十堰地区黄药叶果胶提取工艺及其基本性质研究

中国食品添加剂

-

-

李飞

74

根皮素通过抑制FAK改善肾小管间质纤维化

华中科技大学学报(医学版)

-

-

李飞

75

基于筒鞘蛇菰治疗高尿酸血症的网络药理学分析及其对高尿酸细胞模型和高尿酸血症模型小鼠的治疗作用

吉林大学学报(医学版)

-

-

李飞

76

基于miRNA测序探究重楼皂苷Ⅰ抗炎的关键因子

中国医院药学杂志

-

-

李鹏

77

朱砂精酸生物合成体系的构建和应用

生物工程学报

-

-

李心利

78

课程思政与线上线下混合式在《中药炮制学》课程的探索与构建

畜牧兽医科技信息

-

-

凌旭

79

玉米须多糖的提取及其在护手霜中的应用

山东化工

-

-

凌旭

80

黄花香茶菜甲素靶向ETS1诱导乳腺癌细胞铁死亡的作用机制

湖北医药学院学报

-

-

刘雪文

81

钩毛茜草素C靶向cathepsin D诱导自噬体积累抑制胃癌的作用研究

中国中药杂志

-

-

刘莹

82

乙氧基二氢血根碱靶向EGFR抑制结直肠癌细胞恶性生物学行为并诱导凋亡的机制研究

华中科技大学学报(医学版)

-

-

刘莹

83

基于质谱成像分析黄芩切片主要代谢产物空间分布

湖北医药学院学报

-

-

陆桥

84

白芨根腐病菌腐皮镰孢(Fusarium solani)拮抗菌筛选及抑菌机制

微生物学通报

-

-

孟丽雪

85

原薯蓣皂苷体外抗产NDM-1耐碳青霉烯Raoultella ornithinolytica B1645-1B的机制研究

湖北医药学院学报

-

-

孟丽雪

86

白藜芦醇对帕金森病模型小鼠多巴胺能神经元的保护作用:基于抑制TLR4/MyD88/NF-κB通路

南方医科大学学报

-

-

桑明

87

预知子化学成分、抗消化系统肿瘤药理作用及其药对临床应用研究进展

药物评价研究

-

-

汪选斌

88

重构本草——黄连

吉林中医药

-

-

汪选斌

89

α-常春藤皂苷通过激活和稳定p53/Noxa信号诱导肝癌细胞凋亡

医药导报

-

-

汪选斌

90

中药毒理研究进展

亚太传统医药

-

-

汪选斌

91

金荞麦化学成分、药理作用的研究进展及质量标志物(Q-Marker)的预测分析

广州化工

-

-

王佰灵

92

互联网信息化在以任务为导向的中药药剂学实验教学中的应用

科技风

-

-

王佰灵

93

布洛芬-香豆素杂合衍生物的合成及抗肿瘤活性研究

湖北医药学院学报

-

-

王天帅

94

注射用烟酰胺与4种常用溶媒配伍后稳定性考察

湖北医药学院学报

-

-

魏娟

95

EGFR为靶标的非小细胞肺癌中药天然产物抑制剂的虚拟筛选

中草药

-

-

吴丰旭

96

蜂毒肽Protopolybia-MP及其优化突变体对HSV-1病毒复制周期不同阶段的抑制活性研究

湖北医药学院学报

-

-

叶祥东

97

传统中药材全蝎热稳定性多肽的消化酶抗性研究

湖北医药学院学报

-

-

叶祥东

98

十堰市白菜黑斑病病原真菌的分离与鉴定

湖北农业科学

-

-

张勇洪

99

联合流式细胞术和K-mer分析法测定半蒴苣苔基因组大小

分子植物育种

-

-

张勇洪

100

联合流式细胞术和K-mer分析法测定活血丹基因组大小

分子植物育种

-

-

张勇洪

101

基于抗生素和除草剂敏感性筛选适宜裂叶地黄遗传转化系统的抗性标记

湖北医药学院学报

-

-

张勇洪

102

药用植物虎耳草的DNA条形码鉴定及基因组大小评估

湖北医药学院学报

-

-

张勇洪

103

药用植物冷水花DNA条形码分析和基因组大小测定

湖北医药学院学报

-

-

张勇洪

104

当归补血泡腾片的制备及质量分析

化学试剂

-

-

赵永恒

105

白藜芦醇靶向FLG抑制甲状腺癌细胞增殖、侵袭及迁移

中国医院药学杂志

-

-

朱军


2.专利

序号

授权的专利名称

知识产权编号

申请或授权类型

发明人

1

含布洛芬-香豆素骨架化合物及其应用

ZL 2022 1 1173554.2

授权发明专利

胡扬根

2

洛哌丁胺在逆转结直肠癌5-氟尿嘧啶耐药中的应用

ZL 202410441788.3

授权发明专利

于娟

3

一种金果榄多糖及其制备方法和应用

ZL 2023 1 0473297.2

授权发明专利

郝新才

4

杜鹃兰叶醇提物及其用途

ZL 2023 1 0750326.5

授权发明专利

郝新才

5

武当鸡头黄精熟黄精的制备方法和质量评价方法

ZL 2023 1 0316886.X

授权发明专利

张晓燕

6

大萼变型甲素的新应用

ZL 2022 1 0718493.7

授权发明专利

刘莹

7

连翘苷在制备预防或治疗高尿酸血症的药物中的应用

2024118259090

申请发明专利

李飞

8

根皮素在制备预防或治疗肾缺血再灌注损伤的药物中的应用

202411696106X

申请发明专利

李飞

9

蒙花苷在制备预防或治疗肾纤维化的药物中的应用

202411607448X

申请发明专利

李飞

10

黄药叶药材指纹图谱检测方法

2024102038806

申请发明专利

李飞

11

大黄素联用抗生素在制备防治沙门氏菌感染的药物中的应用

CN202411584383.1

申请发明专利

张勇洪

3.专著

序号

专著名称

年份

出版社

主编或参编人员

1

医学检验技术与临床进展

2024

科学技术文献出版

肖雪

2

现代内科疾病诊断与治疗

2024

湖北科学技术出版社

杨萌

3

临床内科检查与治疗

2024

吉林科学技术出版社

王静晖

4

现代内科疾病诊疗精要

2024

天津科学技术出版社

王静晖

4.奖励

序号

奖励名称

成果编号

奖励类型

获奖人

1

中国藤黄属植物新颖效应物质和作用靶点的发现及创新技术体系构建

202403-03

中华中医药学会科学技术奖三等奖

汪选斌

2

基于结直肠癌发病机制的防治新靶标开发与推广应用

2024J-227-3-106-094

省科技进步三等奖

杜伯雨

3

肿瘤标志物筛选与检测技术体系的构建及推广应用

2024J-227-3-106-092

省科技进步三等奖

武伦

4

肝脏肿瘤智能影像诊断关键技术与应用

2024J-227-3-106-060

省科技进步三等奖

赵亮主持,陈文参与

5

痛与镇痛新范式改善患者健康结局的应用研究

2024J-227-3-106-089

省科技进步三等奖

李龙倜主持,吴艳琼参与

6

基于环境因素提高男性生育力的关键技术创新及应用

2024J-227-3-106-089

省科技进步三等奖

段鹏主持,焦蓉参与

7

基于COVID-19的新发突发传染病精准防控与诊疗体系构建与创新集成应用

2024J-227-3-106-105

省科技进步三等奖

刘志新主持,雷旭参与

5.成果转化

序号

成果名称

完成时间

负责人

经费

(万元)

备注

1

一种葛根红枣保健品的加工装置

2024-06-05

邱婧然

0.5

市场型转化,科研机构将成果技术有偿转让给其他单位进行成果转化

2

大萼变型甲素的开发

2024-04-02

刘莹

0.4

市场型转化,科研机构将成果技术有偿转让给其他单位进行成果转化

3

一种自乳化纳米复乳及其制备方法和应用

2024-04-02

王纠

0.4

市场型转化,科研机构将成果技术有偿转让给其他单位进行成果转化



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