胚胎干细胞研究湖北省重点实验室
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2023年度代表性研究成果
2024-06-15 18:21  


本年度,实验室固定研究成员在学术刊物上发表署名武当特色中药研究湖北省重点实验室论文84篇,其中SCI收录53篇(131区,242)。其中授权发明专利6项,另申请专利14项。主编或参编专著3本,获得中国民族医药学会科技进步三等奖1项,省科技进步三等奖1项。依托国家自然科学基金项目和湖北省卫健委创新团队项目进行了2个项目的成果转化,并取得一定的经济效益和社会效益。

1.论文

序号

论文名称

刊物名称

分区

作者

1

Intergenerational effects of parental [Cnmim]BF4 (n = 4, 6, 8) ionic liquids exposure on zebrafish development based on transcriptomic analysis

The Science of the total environment

1

段鹏

2

WUS-RELATED HOMEOBOX 14 boosts de novo plant shoot regeneration

Plant physiology

1

张勇洪

3

Arabidopsis SMO2 modulates ribosome biogenesis by maintaining the RID2 abundance during organ growth

The Plant journal : for cell and molecular biology

1

张勇洪

4

Flavonoids and saponins: What have we got or missed?

Phytomedicine

1

汪选斌

5

Acetylation of MOB1 mediates polyphyllin II-reduced lysosome biogenesis in breast cancer by promoting the cytoplasmic retention of the YAP/TFEB coactivator complex

Phytomedicine

1

刘莹

6

Linggui Zhugan decoction delays ventricular remodeling in rats with chronic heart failure after myocardial infarction through the Wnt/β-catenin signaling pathway

Phytomedicine

1

陈俊

7

Sculponeatin A promotes the ETS1-SYVN1 interaction to induce SLC7A11/xCT-dependent ferroptosis in breast cancer

Phytomedicine

1

刘莹

8

Copper-mediated chemodynamic therapy with ultra-low copper consumption by doping cupric ion on cross-linked (R)-(+)-lipoic acid nanoparticles

Regenerative biomaterials

1

李兵

9

Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CClsub4/sub-induced liver fibrosis in mice

Food & function

1

余惠凡

10

Prenyllongnols A-D, New Prenylated Acylphloroglucinols that Fight Concanavalin A-Induced Autoimmune Hepatitis

Journal of agricultural and food chemistry

1

郝新才

11

Global Decrease in H3K9 Acetylation in Sorghum Seed Postgermination Stages

Journal of agricultural and food chemistry

1

张勇洪

12

Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry

Journal of agricultural and food chemistry

1

乔嘉璐

13

Ellagitannins-Derived Intestinal Microbial Metabolite Urolithin A Ameliorates Fructose-Driven Hepatosteatosis by Suppressing Hepatic Lipid Metabolic Reprogramming and Inducing Lipophagy

Journal of agricultural and food chemistry

1

李珊

14

Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells

Scientific Reports

2

段超

15

Role of MRPs transporters in pharmacokinetics and intestinal toxicity of irinotecan

Food and chemical toxicology

2

孙荣进

16

Triterpenoid Compounds from Cyclocarya paliurus: A Review of Their Phytochemistry, Quality Control, Pharmacology, and Structure-Activity Relationship

The American journal of Chinese medicine

2

贺海波

17

Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3

Food and chemical toxicology

2

喻青青

18

Recent advances in the synthesis and activity of analogues of bistetrahydroisoquinoline alkaloids as antitumor agents

European journal of medicinal chemistry

2

郭举

19

Role of Computer-Aided Drug Design in Drug Development

Molecules

2

吴丰旭

20

Naringenin prevents nonalcoholic steatohepatitis by modulating the host metabolome and intestinal microbiome in MCD dietfed mice

Food Science Nutrition

2

曹鹏

21

The function of MSP-activated γδT cells in hepatocellular carcinoma

International immunopharmacology

2

杜伯雨

22

Polyphyllin VII induces autophagy-dependent ferroptosis in human gastric cancer through targeting T-lymphokine-activated killer cell-originated protein kinase

Phytotherapy research : PTR

2

刘莹

23

Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1ɑ pathway in Schwann cells

Phytotherapy research : PTR

2

喻青青

24

Quercetin ameliorates non-alcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy

The Journal of nutritional biochemistry

2

曹鹏

25

Molecular mechanisms of hepatoprotective effect of tectorigenin against ANIT-induced cholestatic liver injury: Role of FXR and Nrf2 pathways

Food and chemical toxicology

2

曹鹏

26

Evolution of carbapenem resistance in klebsiella pneumoniae and escherichia coli carrying blaNDM1 gene: imipenem exposure results in sustained resistance memory of strains in vitro

Annals of Clinical Microbiology and Antimicrobials

2

金志雄

27

Spectasterols, Aromatic Ergosterols with 6/6/6/5/5, 6/6/6/6, and 6/6/6/5 Ring Systems from Aspergillus spectabilis

Journal of natural products

2

郝新才

28

Jinyinqingre Oral Liquid alleviates LPS-induced acute lung injury by inhibiting the NF-κB/NLRP3/GSDMD pathway

Chinese Journal of Natural Medicines

2

杜士明

29

Characterization of the Molecular Diversity and Degranulation Activity of Mastoparan Family Peptides from Wasp Venoms

Toxins

2

叶祥东

30

Comparison of the molecular mechanisms of Fuzi Lizhong Pill and Huangqin decoction in the treatment of the cold and heat syndromes of ulcerative colitis based on network pharmacology

Computers in Biology and Medicine

2

吴丰旭

31

An integrated network pharmacology approach reveals that Darutigenol reduces inflammation and cartilage degradation in a mouse collagen-induced arthritis model by inhibiting the JAK-STAT3 pathway

Journal of ethnopharmacology

2

何雪莱

32

SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria

Virologica Sinica

2

乔嘉璐

33

Enantioselective Labeling of Zebrafish for D-Phenylalanine Based on Graphene-Based Nanoplatform

Molecules

2

马俊凯

34

The role of myeloid-derived immunosuppressive cells in cardiovascular disease

International Immunopharmacology

2

陈俊

35

Transcriptomic and metabolomic insights into the defense response to HFRs in Arabidopsis

Ecotoxicology and Environmental Safety

2

张勇洪

36

Linggui Zhugan Decoction activates the SIRT1-AMPK-PGC1α signaling pathway to improve mitochondrial and oxidative damage in rats with chronic heart failure caused by myocardial infarction

Frontiers in pharmacology

2

陈俊

37

Ferroptosis as an emerging therapeutic target in liver diseases

Frontiers in pharmacology

2

曹鹏

38

Tormentic acid, a triterpenoid isolated from the fruits of Chaenomeles speciose, protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CXCR4/CXCL12/PLC/PKC/Rho a/MLC pathway

Pharmaceutical biology

3

余惠凡

39

Estimating the sensory-associated metabolites profiling of matcha based on PDO attributes as elucidated by NIRS and MS approaches

Heliyon

3

左雅敏

40

Development and validation of a sensitive and simple LC-MS/MS method for simultaneous quantitation of valsartan, sacubitril and sacubitrilat in pediatric population

Journal of pharmaceutical and biomedical analysis

3

曹鹏

41

Biomarkers for Diagnosing and Treating Fetal Growth Restriction

Current medicinal chemistry

3

贺海波

42

Design, synthesis, and biological evaluation of simplified tetrahydroisoquinoline analogs

Archiv der Pharmazie

3

胡扬根

43

The protective effects of uric acid against myocardial ischemia via the Nrf2 pathway

European journal of pharmacology

3

张琼

44

Characterization of the Hemolytic Activity of Mastoparan Family Peptides from Wasp Venoms

Toxins

3

陈宗运

45

Resveratrol Inhibits Hepatocellular Carcinoma Progression Through Regulating Exosome Secretion

Current medicinal chemistry

3

严世荣

46

LncRNA XXYLT1-AS2 promotes tumor progression via autophagy inhibition through ubiquitinated degradation of TFEB in hepatocellular carcinoma

Clinical and Translational Oncology

3

严世荣

47

Novel Coumarin-furo[2,3-d]pyrimidinone Hybrid derivatives as anticancer agents: Synthesis, biological evaluation and Molecular Docking

European journal of pharmaceutical sciences

3

胡扬根

48

Intergenerational toxic effects of parental exposure to [Cn mim]NO3 (n = 2,4,6) on nervous and skeletal development in zebrafish offspring

Environmental toxicology

3

段鹏

49

Transcriptional profiling of long noncoding RNAs associated with flower color formation in Ipomoea nil

Planta

3

张勇洪

50

The Role of Glucagon-Like Peptide-1 Receptor Agonists in Chronic Obstructive Pulmonary Disease

International journal of chronic obstructive pulmonary disease

3

陈俊

51

The efficacy of immunosuppressive drugs induction therapy for lupus nephritis: a systematic review and network meta-analysis

Renal failure

3

赵利军

52

Possible therapeutic targets for NLRP3 inflammasome-induced breast cancer

Discover. Oncology

4

王明华

53

Neuroligins facilitate the development of bone cancer pain via regulating synaptic transmission: an experimental study

Brazilian journal of anesthesiology (Elsevier)

4

柯昌斌

54

模糊数学结合响应面法优化甘草桔梗复合饮料配方

食品与发酵科技


郝新才

55

天麻素通过抑制AKT/NLRP3通路改善BV-2小胶质细胞焦亡

世界科学技术-中医药现代化


王雨

56

基于“肠-脑轴”理论探讨固本健脑复方对AD模型大鼠肠道菌群、TLR4/NF-κB通路的影响

时珍国医国药


王雨

57

三种Mastoparan胡蜂多肽的抗菌功能和分子优化研究

湖北医药学院学报


叶祥东

58

十堰地区连翘叶HPLC指纹图谱的建立及抗氧化抑菌谱效关系研究

饲料研究


马俊凯

59

广藿香酮对肺癌PC-9细胞增殖和凋亡的影响

中国医院药学杂志


李志浩

60

大黄酰氨基酰胺类衍生物的合成及其抗菌活性

林产化学与工业


赵利军

61

基于金属有机框架的纳米酶及医学应用进展

当代化工


张琼瑶

62

人脐带血血浆外泌体调控帕金森病小鼠免疫反应发挥神经保护作用的研究

中国病理生理杂志


桑明

63

秦巴山不同产区连翘叶中多酚类化合物含量分析

职业与健康


周灿

64

基于ZIF-8-Ce模拟酶的高效比色法检测谷胱甘肽的研究

中国药学杂志


徐靖

65

超高效液相色谱指纹图谱结合化学模式识别分析艾叶质量

理化检验-化学分册


郝新才

66

柴胡4种活性成分的体外抗氧化作用

医药导报


杜士明

67

UPLC-PDA法同时测定柴胡中3种皂苷的含量

食品与药品


魏娟

68

次大风子素通过CNOT4介导的YAP泛素化降解抑制三阴性乳腺癌恶性进展的作用研究

中国中药杂志


刘雪文

69

基于网络药理学和实验验证探讨木瓜抗胃衰老的作用机制

中国药学杂志


贺海波

70

冻融胚胎移植后发生异位妊娠的相关影响因素分析

中国妇幼保健


江胜芳

71

武当山地区山慈菇药材质量研究

湖北医药学院学报


郝新才

72

HPLC法评价不同产地柴胡药材的质量

湖北医药学院学报


赵利军

73

中性粒细胞胞外诱捕网在肾脏疾病中的作用

华中科技大学学报(医学版)


李飞

74

UPLC-MS/MS法测定蛇菰中7种成分含量及其活性成分没食子酸的降尿酸作用研究

中药药理与临床


李飞

75

GPS2降低表皮生长因子受体稳定性抑制胃癌恶性进展

湖北医药学院学报


司渊

76

杜鹃兰叶总黄酮提取工艺的优化及抗氧化活性研究

湖北医药学院学报


郝新才

77

多巴胺改性粉煤灰化学镀银工艺

电镀与涂饰


马俊凯

78

西蒙一号红薯凉粉的加工工艺优化及品质分析

粮食与油脂


郝新才

79

蒙花苷体内外降尿酸作用及对高尿酸血症小鼠尿酸转运蛋白的影响

中药药理与临床


李飞

80

重楼皂苷激活Hippo信号诱导结直肠癌细胞凋亡及自噬的作用机制

中国实验方剂学杂志


司渊

81

3-芳基-2-亚胺-苯并[e]-1,3-噁嗪-4-醇衍生物的合成及活性评价

有机化学


胡扬根

82

附子抗心律失常作用机制研究进展

中国医院药学杂志


朱军

83

甘草黄酮醇降尿酸及抑制氧化应激作用及其机制研究

中国现代应用药学


李飞

84

蒙花苷药理作用研究进展

中药药理与临床


李飞


2.专利

序号

授权的专利名称

知识产权编号

申请或授权类型

发明人

1

长柄臭黄荆果胶速效凝固剂的研制及果胶制备工艺

ZL 2021 10325012.1

授权发明专利

汪选斌等

2

蒙花苷在制备调节尿酸分泌蛋白的药物中的应用

ZL202210708308.6

授权发明专利

李飞等

3

环多肽2-苯乙烯基-5-吡咯烷酮-2-酰胺衍生物、制备方法及其应用

ZL201911154266.0

授权发明专利

曾小华

4

一种葛根红枣保健品的加工装置

ZL202210076229.8

授权发明专利

邱婧然 等

5

一种乙氧基血根碱纳米乳及其制备方法和应用

ZL202111026015.1

授权发明专利

刘莹等

6

一种覆盖TF-PEG-PLGA涂层的载药ZIF-8纳米粒及其制备方法与应用

ZL202210486787.1

授权发明专利

方兴刚等

7

几种呋喃并嘧啶-布洛芬杂合衍生物的合成方法及抗肿瘤的应用

CN116731030A

申请发明专利

胡扬根等

8

一种金果榄多糖及其制备方法和应用

CN116693716A

申请发明专利

郝新才等

9

杜鹃兰叶醇提物及其用途

CN116585425A

申请发明专利

郝新才等

10

一种山慈菇提取物及其制备方法和用途

CN116509962A

申请发明专利

郝新才等

11

一组多肽TSM1突变体及其应用

CN116589563A

申请发明专利

叶祥东等

12

胡蜂毒液多肽Protonectarina-MP及其抗病毒应用

CN116535468A

申请发明专利

叶祥东等

13

一组金环蛇抗凝肽BF9的突变体及其应用

CN116478272A

申请发明专利

叶祥东等

14

一组抗凝和/或抗补体的多肽组及其应用

CN116444650A

申请发明专利

叶祥东等

15

武当鸡头黄精熟黄精的制备方法和质量评价方法

CN116370572A

申请发明专利

张晓燕等

16

一种具有抗肺癌活性的化合物及其制备方法和应用

CN116554078A

申请发明专利

曾小华等

17

一种绞股蓝栽培盒

CN220044285U

申请实用新型

张勇洪等

18

一种绞股蓝冷却摊晾平台

CN219955903U

申请实用新型

张勇洪等

19

一种绞股蓝清洗干燥装置

CN219899338U

申请实用新型

张勇洪等

20

一种绞股蓝成品收割装置

CN219812525U

申请实用新型

张勇洪等

3.专著

序号

专著名称

年份

出版社

主编或参编人员

1

《中药毒理学》

2023

上海科学技术出版社

徐宏喜、冯奕斌、汪选斌(主编)

2

《武当中医效验秘方集解》

2023

湖北科技出版社

汪选斌,施斌,黄斌主编;时文远、李洪亮、黄梅花等副主编、编委

3

生活中的毒理学

2023

上海科学技术出版社

顾新生


4.奖励

序号

奖励名称

成果编号

奖励类型

负责人

1

天然产物防治尿酸性肾病的分子机制及健康产品开发应用

202303-12

中国民族医药学会科技进步三等奖

李飞

2

秦巴山区特色药用植物活性成分开发与利用

2023J-369-3-091-086-R01

省科技进步三等奖

郝新才

5.成果转化

序号

成果名称

完成时间

负责人

经费

(万元)

备注

1

一种白及多糖/生物玻璃温敏凝胶剂及其制备方法和应用

2023-04-04

郝新才

10.00

市场型转化,科研机构将成果技术有偿转让给其他单位进行成果转化

2

一种二氯二茂钛的合成方法

2023-05-21

王天帅

5.00

市场型转化,科研机构将成果技术有偿转让给其他单位进行成果转化



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